ENDO-FLEX clip system enables safe application of hemostasis clips, for marking and closing of tissue and vascular lesions of the mucosa and submucosa and for hemostasis. The clips are pre-loaded and can be opened and closed several times for repositioning. A simple firing mechanism facilitates the precise placement of the clip. The optimized shaft and clip length enables safe application for a firm tissue seal. Several clip lengths are available for use in a variety of clinical situations. The rotation function ensures a precise positioning of the clip, even in complicated positions.